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Description:
Rat Insulin-like Growth Factor Binding Protein-4 (rIGFBP-4) is a 233 amino acid glycosylated protein that is one of the six “classical” IGF binding proteins that play an important role in stabilizing and regulating the activity of IGFs in vivo. Rat IGFBP-4 binds both IGF-I and IGF-II and modifies their biological activity and bioavailability.
References:
Chelius D. et al. (2001) J. Endocrinol. 168, 283-296
Chemausek S.D. et al. (1995) J. Biol. Chem. 270, 11377-11382
Source:
Produced recombinantly in E.coli.
Purified by affinity and other chromatographic steps.
Purity:
> 95% rat IGFBP-4 (by Mass Spectrometry)
Molecular Weight:
25.7 kDa (non-glycosylated)
Biological Activity:
Binding of IGF-I: IC50 0.24 nM
State and Appearance:
Lyophilized white powder dried from 10mM HCl and stored under dry nitrogen at a slight vacuum (-25 kPa).
Storage/Stability:
At least 2 years at 2 - 4°C (lyophilized).
Reconstitution:
#1100: Handling of Novozymes GroPep IGF Binding Proteins 1-6
Detection:
#3130: Procedure for Iodination of rat IGFBP-4
#3131: Determination of rat IGFBP-4 by Radioimmunoassay (RIA)
#3100: Immunohistochemical (IHC) Detection of IGFBPs In Paraffin Sections Of Rat Embryonic Tissues Using Extravidin-Cy3 Staining
Related Products:
IGFBP-4, anti-rat
Rat IGFBP-4 Pack
IGFBP-4, antibody for Immunohistochemistry
IGFBP-4 Immunohistochemistry Pack
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