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Description:

Human Insulin-like Growth Factor Binding Protein-2 (IGFBP-2) is a 289 amino acid protein that is one of the six “classical” IGF binding proteins that play an important role in stabilizing and regulating the activity of IGFs in vivo. hIGFBP-2 binds both IGF-I and IGF-II and modifies their biological activity and bioavailability.

References:

Zapf J. (1995) Eur. J. Endocrinol. 132, 645-654
Clemmons, D.R. (1998) Molec. & Cell. Endocrinol., 140, 19-24

Source:

Produced recombinantly in mammalian cells. Purified by affinity and other chromatographic steps.

Purity:

>95% (by HPLC and Mass Spectrometry)

Molecular Weight:

31.3 kDa

Biological Activity:

Single species detected by Western ligand blot using ¹²⁵I-IGF-I as probe.

State and Appearance:

Lyophilized white powder dried from 0.1% TFA / 30% acetonitrile and stored under dry nitrogen at a slight vacuum (-25 kPa).

Storage/Stability:

At least 2 years at 2 - 4°C (lyophilized).

Reconstitution:

#1100: Handling of GroPep Bioreagents IGF Binding Proteins 1-6

Detection:

#3100: Immunohistochemical (IHC) Detection of IGFBPs In Paraffin Sections Of Rat Embryonic Tissues Using Extravidin-Cy3 Staining

#3110: Protocol for Western Immunoblotting using human IGFBP antisera

Related Products:

IGFBP-2, anti-human

IGFBP-2, antibody for Immunohistochemistry

Human IGFBP-2 Pack

IGFBP-2 Immunohistochemistry Pack